Pharmacokinetics of Caninsulin^®

Caninsulin is an aqueous suspension of 40 IU highly purified porcine insulin per ml, consisting of 30% amorphous and 70% crystalline zinc insulin.

In dogs the amorphous fraction has peak activity approximately 3 hours after subcutaneous administration and its effects last for about 8 hours. Thereafter, the effect is maintained by the crystalline fraction, which has a slower onset of action and peak effects from 7 to 12 hours following injection. Afterwards, the effect gradually declines to zero.

In cats, the total duration of action is around 12 hours.