Changes in Insulin Requirements in Diabetic Dogs

"It is not unusual for insulin requirements to change suddenly even after a long period of stability. "


Dose adjustment

Dose adjustment should be based on the clinical response and the interpretation of a serial blood glucose curve. Ideally a blood glucose curve should be made before the insulin dose is changed.

Urine glucose and ketone monitoring can be used to check whether a blood glucose curve should be made, it should not be used on it's own as a basis for dose adjustment.

Dose adjustment should be made in steps of 10%, rounded down to the nearest whole or half unit. Changes in dose should be made after a period of adjustment to a particular dose or regime, i.e. at least 3-4 days.

Changes in Insulin Requirements in Diabetic Dogs

Changes in insulin requirements can be due to a number of factors

  • infection (e.g. urinary tract infection (cystitis), (pyoderma)
  • altered exercise regime
  • weight loss or gain
  • other concurrent illness (e.g. renal failure, heart failure)
  • other concurrent endocrine disease
  • metoestrus in dogs - changes in progesterone concentrations
  • corticosteroid or progestogen administration